A Comparative Study of Thyroid Hormone and Lipid Status in Diabetic and Non Diabetic Adults

The alteration of thyroid function in Type 1 and Type 2 diabetes has been shown in many studies. In previous two studies performed at BIRDEM on thyroid function, it has been found that thyroid functions were altered in diabetic subjects. The study population consisted of 120 subjects divided into two groups; diabetic (n=60) subjects and non diabetic (n=60) subjects with control (n=30) subjects. In order to clarify the mechanism of impaired thyroid hormone levels in patients with diabetes, blood glucose, glycosylated hemoglobin (HbA1C), lipids, thyroid stimulating hormone(TSH), free T4 (FT4) was observed in diabetic patients compared to non diabetic and control subjects. The mean age and body mass index (BMI) were significantly (p<0.001) increased in diabetic patients compared to non diabetic and control patients. A significantly (P<0.001) increased in the levels of serum cholesterol, triglyceride, lowdensity lipoprotein (LDL-C) were observed in diabetic patients compared to non diabetic and control subjects, and high density lipoprotein (HDL-C) were significantly (P<0.05) decreased in diabetic patients compared to non diabetic patients. The level of TSH in diabetic patients were significantly (P<0.05) increased compared to non diabetic and control subjects. But free T4 did not differ significantly in diabetic patients compared to non diabetic and control subjects. In conclusion, our findings demonstrate that detection of dyslipidemia and abnormal thyroid hormone levels in the early stage of diabetes mellitus will help the patients to improve quality of life and reduce the morbidity rate. A Comparative Study of Thyroid Hormone and Lipid Status in Diabetic and Non Diabetic Adults